Phil Scott DVM&S, DipECBHM, CertCHP, DSHP, FRCVS
Reviewed byPhil Scott DVM&S, DipECBHM, CertCHP, DSHP, FRCVS 2016
Trace Element Deficiencies in Sheep
The clinical signs associated with trace element deficiency in sheep are often insidious in onset and usually present as poorly grown lambs during late summer/early autumn. There is considerable interplay between parasitic gastroenteritis (PGE) and trace element deficiency states such that it is important for the farmer and veterinary practitioner to consider and deal with both problems.
The trace element deficiency states generally considered are: cobalt, copper, and vitamin E and selenium
Fig 1: Poor quality wool with an open fleece, small size and poor body condition caused by cobalt deficiency in weaned lambs- pine.
Cobalt has an important biological role as a constituent of vitamin B12 which is manufactured by micro-organisms in the first stomach (rumen). Cobalt deficiency (pine) occurs where there are low soil cobalt concentrations which may be further complicated by PGE which causes diarrhoea thereby interfering with the absorption of vitamin B12.
Fig 2: Pine and parasitic gastroenteritis causing emaciation in five month-old weaned lambs.
Clinical signs of cobalt deficiency are most commonly observed in weaned lambs at pasture during late summer/autumn. Signs include lethargy, reduced appetite, poor quality wool with an open fleece, small size and poor body condition despite adequate nutrition. There may be tear staining of the cheeks, and pale mucous membranes (eyes) develop after several months. Cobalt-deficient sheep may fail to respond well to vaccinations and be more susceptible to clostridial diseases (for example pulpy kidney) and pasteurellosis (pneumonia).
In severe cases of cobalt deficiency (referred to as ovine white liver syndrome) lambs present with nervous signs including depression, head pressing, and aimless wandering.
Cobalt deficiency is much less common in adults but is reported to cause reduced fertility and poor mothering ability but these signs may be more related to generalised low body condition scores.
Fig 3: Pine causing poor growth in weaned lambs.
There is considerable interaction between chronic parasitism and trace element deficiency states such that it may prove difficult to ascertain which is the more important condition. Diagnosis is often compounded by the fact lambs may have been recently treated with an anthelminitic and moved onto better pasture immediately before veterinary examination.
Fig 4: Severe cobalt deficiency.
The main differential diagnoses for cobalt pine your veterinary practitioner will consider include:
Poor ewe nutrition/overstocked pasture mean that lambs do not grow well
Poor grazing/overstocked pasture after weaning.
Coccidiosis and/or severe nematodirosis can cause a serious growth check often around 6 to 8 weeks-old with protracted convalescence.
Parasitic gastro-enteritis is a very common cause of poor lamb growth
Fig 5: Severe cobalt deficiency causing depression and head pressing.
Diagnosis is based upon clinical signs in areas with known cobalt-deficient soils supported by specific diagnostic tests undertaken by the farmer's veterinary surgeon including low plasma and/or liver vitamin B12 concentrations. As a general guide, a positive growth response to supplementation is expected if the mean plasma vitamin B12 concentration is < 500pg/ml, and is likely to be significant where it had been below 250pg/ml. A minimum of 10 blood samples is recommended to determine the mean plasma vitamin B12 concentration but this number is likely to be limited by cost considerations. These blood samples must be collected as soon as possible after the sheep have been gathered as values increase significantly within hours of confinement.
The veterinary practitioner may advise a supplementation trial whereby growth rates of supplemented and control lambs are measured over eight to 10 weeks and. Typically, a 4 to 6 kg improvement in growth rate over controls would be expected over eight to 10 weeks of supplementation. Where cobalt deficiency is suspected, 10 to 12 lambs could be left untreated until such time as a demonstrable difference could be appreciated thereby reducing the impact of leaving lambs without cobalt supplementation.
Fig 6: Parasitic gastro-enteritis is a very common cause of poor lamb growth
Treatment is more quickly effected by a combination of intramuscular injection of vitamin B12 and drenching with up to 1 mg/kg bodyweight of cobalt sulphate. Thereafter, monthly drenching with cobalt sulphate, often in combination with an anthelmintic preparation, should ensure liveweight gain.
Oral cobalt supplementation is very cheap indeed and, where appropriate, can be added to certain anthelmintic drenches. Monthly dosing lambs from around three months-old with cobalt drenches should supply sufficient cobalt to growing lambs in most situations.
Cobalt containing boluses, which lodge in the reticulum (second stomach), provide a continuous supply of cobalt but are expensive in those lambs which require supplementation for only two to three months.
Soluble glass boluses containing cobalt, selenium and copper are an expensive means of supplying cobalt and are only indicated in situations where all deficiency conditions are considered to exert a negative influence on health.
Fig 7: Monthly dosing lambs from around three month-old with cobalt drenches should supply sufficient cobalt to growing lambs in most situations.
Oral cobalt supplementation costs less than 1 penny per 25 kg lamb. Production losses from poor growth and delays to marketing may cost £10-£15 per lamb.
Fig 8: Swayback causing hind leg weakness in a young lamb.
Copper deficiency is common when sheep graze pastures low in copper but more often high in iron, molybdenum and sulphur. Where two or more of these three elements exist together on a farm, in quite 'normal' concentrations, they will act synergistically to bind out copper from a diet. The clinical manifestation of copper deficiency varies worldwide with swayback more common in the UK, poor wool quality and anaemia in Australia, and poor bone mineralization in New Zealand.
As well as being susceptible to copper deficiency, sheep are also prone to copper accumulation and toxicity. There is considerable breed variation with respect to copper absorption and therefore to copper deficiency and toxicity. Veterinary advice is essential before copper supplementation to sheep.
Fig 9: Copper poisoning - timing and type of copper supplementation must be specified in the farm's veterinary flock plan
Copper deficiency in ewes during mid-pregnancy may lead to swayback in lambs.
In growing lambs copper deficiency may result in a poor fleece without its natural "crimp" which has been described as "steely wool". Poor growth, anaemia, and increased susceptibility to bacterial infections has been reported but is much less common in the UK.
Swayback is provisionally diagnosed by the veterinary practitioner on clinical examination and confirmed following histopathological examination of the central nervous system.
Copper deficiency is most reliably diagnosed in growing lambs based upon a dose/response study (see above under cobalt supplementation noting veterinary advice is essential before giving copper supplements).
Plasma samples are most commonly submitted for laboratory analysis by the veterinary practitioner with concentrations below 9.4 μmol/L indicating depletion of liver reserves. It is reported that lamb growth rates are not adversely affected until plasma concentrations fall below 3 μmol/L.
Differential diagnoses include vertebral body empyema (spinal abscess) and sarcocystosis.
Prevention of copper deficiency in growing lambs is much more important than treatment because irreversible changes have often taken place in the fleece, and full compensatory growth may not result after supplementation. Furthermore, treatment of swayback is hopeless and emphasis must be placed upon preventive measures.
While copper deficiency is often a perennial problem on certain farms, farmers must always be made aware of the risks of copper toxicity. Therefore timing and type of copper supplementation must be specified in the farm's veterinary flock plan with specific notes made regarding no other source of extra copper. Sheep must not be given a copper supplement prior to, or during, housing. Toxicity could result from a number of sources including using more than one method of copper supplementation, and use of feeds with high copper content.
Copper is usually given by injection as copper heptonate. Certain copper injections are irritant and may cause a localised reaction. Care must be exercised that the injection is given correctly because abscessation, and in some cases tracking of infection to the spinal canal, have been observed after incorrect injection technique
Supplementation with copper oxide needles can be administered orally in a gelatin capsule. Sheep should not be re-treated for 12 months unless signs of copper deficiency recur.
Appropriate supplementation of the ewe during mid-gestation will prevent the development of swayback in her newborn progeny.
Copper supplementation costs between 30 pence to £1 for injectable preparations and gelatin capsules containing copper oxide needles, respectively.
Fig 10: White muscle disease affecting a rapidly growing two week-old lamb
Selenium and vitamin E deficiency
Often referred to as white muscle disease, nutritional muscular dystrophy, and stiff lamb disease
White muscle disease occurs in the UK with recognised risk factors such as feeding home grown cereals and root crops, and incorrectly mineralised rations; however the disease prevalence is generally low. Selenium deficiency occurs in soils of certain geographic areas world-wide leading to pasture/crop deficiency. Vitamin E concentrations are high in green crops but fall rapidly under drought conditions. Certain root crops are known to be low in both selenium and vitamin E. Feeding grain treated with propionic acid may increase the risk of white muscle disease.
In the UK, white muscle disease typically affects rapidly-growing two to six week-old lambs; often ram lambs of meat breeds such as the Suffolk and Texel. There is sudden onset stiffness with lambs reluctant to move such that they are easily caught. After one or two days, affected lambs are unable to rise.
Selenium-responsive poor growth in lambs has been reported in certain geographic areas of Australia and New Zealand where dramatic improvements have resulted after supplementation. Improved lamb growth rates after selenium supplementation are less commonly reported in the UK but will depend upon soil type and localised problems may exist.
Early embryonic loss/failure to implant after mating has been attributed to selenium deficiency. In ewes an increased lamb crop with fewer barren ewes has been reported after selenium supplementation before the mating period but these responses were highly variable between flocks.
The main differential diagnosis for stiffness leading to recumbency in lambs less than two weeks-old is bacterial infection of a joint in the neck and it is very important that this problem is investigated by a veterinary practitioner.
There are many causes of poor growth in groups of growing lambs including cobalt deficiency, poor pasture management, and parasitic gastro-enteritis. Likewise there are many causes of returns to service including infertile rams (ewes returning at 17 day intervals), toxoplasmosis and Border disease (ewes returning at intervals greater than 17 days).
A provisional diagnosis of white muscle disease in young lambs is based upon clinical signs in rapidly growing healthy lambs with the presence of some of the risk factors listed above. Muscle enzyme concentrations will be measured by the veterinary practitioner. Most laboratories determine glutathione peroxidase as the indicator of selenium status.
Intramuscular or subcutaneous injection of young lambs suffering from white muscle disease with 0.75 to 1.5 mg selenium as potassium selenate and 34 to 68 mg vitamin E (dl a-tocopherol acetate) results in return to full mobility within two to three days.
A range of methods can be used to supply selenium and/or vitamin E including in-feed medication, periodic drenching, depot injection, and intraruminal glass bolus or pellet. It is generally accepted that free-access licks/minerals are unreliable because of highly variable intakes.
As white muscle disease is seen most commonly in young lambs, prevention can be achieved by supplementation of the dam's ration during late gestation or injection of all newborn lambs with a selenium and vitamin E preparation.
Supplementation of growing lambs is best achieved by drenching, often in combination with anthelmintic treatment. Such supplementation provides adequate selenium for one to three months. Great care must be exercised when formulating a supplementation programme because toxicity can occur following over-dosage especially in young lambs. The preparation must be shaken vigorously prior to use to ensure thorough mixing. In breeding sheep, selenium supplementation via drenching is given one to two months before the start of the breeding season. It is essential that veterinary advice is obtained before supplementation.
Intraruminal glass boluses are a very expensive means of supplementing with selenium but is a useful method where other trace element deficiency states occur concurrently.
In the absence of a split flock trial, it is very difficult to calculate the cost benefit of selenium supplementation with respect to reproductive wastage. If doubts exist regarding poor reproductive performance, ewes should be drenched at regular intervals prior to mating.
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